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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERN1 All Species: 16.67
Human Site: Y83 Identified Species: 28.21
UniProt: O75460 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75460 NP_001424.3 977 109735 Y83 D P N D G S L Y T L G S K N N
Chimpanzee Pan troglodytes XP_511585 968 108684 H80 D V D Y K M S H F V S N G D G
Rhesus Macaque Macaca mulatta XP_001109583 1070 119711 Y176 D P N D G S L Y T L G S K N N
Dog Lupus familis XP_853409 975 109686 Y83 D P N D G S L Y T L G G K N N
Cat Felis silvestris
Mouse Mus musculus Q9EQY0 977 110166 Y85 D P N D G S L Y T L G G K N N
Rat Rattus norvegicus XP_573211 965 109012 L83 G G K N N E G L T K L P F T I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510886 942 106736 D81 A S P C R S S D G I L Y M G K
Chicken Gallus gallus
Frog Xenopus laevis NP_001085649 958 108223 Y88 D P S D G S L Y I L G G R N K
Zebra Danio Brachydanio rerio XP_001919350 921 102695 G81 D G S L Y V L G G K R K E G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097839 1074 120152 D82 I R W T I A D D P P I V A E H
Honey Bee Apis mellifera XP_392044 968 110555 D81 N I L W R Q N D E P I V K V P
Nematode Worm Caenorhab. elegans Q09499 967 109804 L95 P N P L D G S L Y V L K N S S
Sea Urchin Strong. purpuratus XP_786178 1112 123199 L105 P D P T D G T L Y V L G P G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32361 1115 126957 N83 L S S Y P T P N L L N T A D N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.7 90.3 95.5 N.A. 93.1 92.1 N.A. 83 N.A. 56 57 N.A. 37.7 43 41.3 41.4
Protein Similarity: 100 84.8 91 97.3 N.A. 96.3 94.8 N.A. 89.3 N.A. 71.4 69.8 N.A. 52.9 58.6 59.3 54.4
P-Site Identity: 100 6.6 100 93.3 N.A. 93.3 6.6 N.A. 6.6 N.A. 66.6 13.3 N.A. 0 6.6 0 0
P-Site Similarity: 100 40 100 93.3 N.A. 93.3 13.3 N.A. 13.3 N.A. 80 26.6 N.A. 13.3 13.3 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 8 0 0 0 0 0 0 15 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 50 8 8 36 15 0 8 22 0 0 0 0 0 15 0 % D
% Glu: 0 0 0 0 0 8 0 0 8 0 0 0 8 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % F
% Gly: 8 15 0 0 36 15 8 8 15 0 36 29 8 22 15 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % H
% Ile: 8 8 0 0 8 0 0 0 8 8 15 0 0 0 8 % I
% Lys: 0 0 8 0 8 0 0 0 0 15 0 15 36 0 15 % K
% Leu: 8 0 8 15 0 0 43 22 8 43 29 0 0 0 8 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % M
% Asn: 8 8 29 8 8 0 8 8 0 0 8 8 8 36 36 % N
% Pro: 15 36 22 0 8 0 8 0 8 15 0 8 8 0 8 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 0 0 15 0 0 0 0 0 8 0 8 0 0 % R
% Ser: 0 15 22 0 0 43 22 0 0 0 8 15 0 8 8 % S
% Thr: 0 0 0 15 0 8 8 0 36 0 0 8 0 8 0 % T
% Val: 0 8 0 0 0 8 0 0 0 22 0 15 0 8 0 % V
% Trp: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 15 8 0 0 36 15 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _